People with a type of early stage peritoneal mesothelioma may have better results when they have surgery and intraperitoneal chemotherapy using a laparoscope rather than an open procedure.
A small study in France compared outcomes for patients with peritoneal surface malignancies like mesothelioma and found that, for certain patients, the minimally-invasive laparoscopic approach was better than the open one. The study followed patients with a low-grade form of multicystic mesothelioma, a type of mesothelioma that presents as small cysts on the abdominal lining (peritoneum), or another type of cancer called pseudomyxoma peritonei.
Between January 2011 and November 2012, all 8 of these patients were operated on through small incisions with the guidance of an internal camera called a laparoscope. After cytoreduction (CRS – removal of the tumors), these patients’ abdominal cavities were rinsed with a heated solution of chemotherapy drugs (HIPEC) to kill any residual cancer cells. Their results were compared with those of 8 other patients with similar low-grade mesothelioma or other peritoneal malignancies who were operated on using an open procedure (laparotomy).
The data suggest that the minimally-invasive laparoscopic approach results in fewer complications and shorter hospital stays. In the laparoscopic surgery group, all patients had their mesothelioma tumors successfully removed through the small incisions, without having to convert to the more invasive version of the surgery. These mesothelioma patients were also in surgery for a half an hour less than their open-procedure counterparts – 210 minutes with the laparoscope vs. 240 minutes for laparotomy.
Among patients who had laparoscopic surgery, only one had a postoperative complication, vs. 4 in the laparotomy group. Finally, the laparoscopic surgery patients were able to go home from the hospital a week sooner than those who had the open procedure. Mesothelioma patients and others in the study who underwent laparotomy were in the hospital for a median of 19 days.
The cancer researchers who conducted the study say the key is carefully choosing the mesothelioma patients and others who are candidates for this approach. Patients with low-grade cancer are likely to get the most benefit from the less-risky procedure. “Laparoscopic CRS combined with HIPEC is feasible and safe for curative treatment of strictly selected patients with peritoneal surface malignancy and might reduce postoperative complications and length of hospital stay,” the research team concludes. Their results were published in the European Journal of Surgical Oncology.
Disclaimer: The information in this article is for educational and informational purposes only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read in this article. This article was written by a third party and its content reflects the views of the third party and does not necessarily reflect the views or opinions or of Surviving Mesothelioma or Cancer Monthly.
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